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Research in the Barry laboratory combines molecular biophysics, spectroscopy, biochemistry, and chemical biology to study enzyme based catalysis. The role of metal ions in proton coupled electron transfer (PCET) reactions are of particular interest and are fundamental to solar energy conversion and DNA synthesis. New projects seek to synthesize biomimetic maquettes that can conduct PCET reactions, to define the role of intrinsically disordered peptides in the immune system, and to describe DNA-cisplatin interactions in vivo and in vitro.
- A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase
- Water Bridges Conduct Sequential Proton Transfer in Photosynthetic Oxygen Evolution
- Structure and Function of Tryptophan–Tyrosine Dyads in Biomimetic β Hairpins
- Tyrosine, cysteine, and proton coupled electron transfer in a ribonucleotide reductase-inspired beta hairpin maquette