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The Barry lab generates new knowledge concerning protein-based catalysis. Research foci include the enzymes involved in oxygenic photosynthesis and DNA synthesis. This information will contribute to improvements in artificial solar energy conversion and in the treatment of disease. Students in the Barry lab develop and use a wide variety of biochemical and biophysical techniques, including spectroscopy, biomimetics, and chemical biology. The research is highly interdisciplinary and collaborative.
- A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase
- Water Bridges Conduct Sequential Proton Transfer in Photosynthetic Oxygen Evolution
- Structure and Function of Tryptophan–Tyrosine Dyads in Biomimetic β Hairpins
- Tyrosine, cysteine, and proton coupled electron transfer in a ribonucleotide reductase-inspired beta hairpin maquette